Tetrazine-NHS Ester

Catalog#
Unit Size
Price (USD)
Availability
Qty
1127-25
25 mg
$130.00
In stock
1127-100
100 mg
$379.00
In stock
1127-500
500 mg
$1,050.00
In stock
1127-1000
1000 mg
$1,550.00
In stock

    Tetrazine-NHS Ester demonstrates exceptionally fast cycloaddition kinetics (up to 30 000 M-1 s-1) with trans-cyclooctene (TCO) as the dienophile, the fastest kinetics ever reported for any bioorthogonal reaction. The chemical stability tetrazines is substantially lower compared to Methyltetrazines, which requires more careful selection of reagents and conditions for chemical transformation, however it is in acceptable range for many applications.

    This product is not recommended for labeling of proteins or any other biopolymers in aqueous buffers due to poor aqueous solubility.

    Molecular weight
    313.27
    Chemical composition
    C14H11N5O4
    CAS
    1616668-55-3
    Solubility
    DMSO, DMF, DCM, THF, Chloroform
    Purity
    >95% (HPLC)
    Appearance
    Red crystalline
    Storage conditions
    -20°C. Desiccate
    Shipping conditions
    Ambient temperature

    1. Sun, N., et al. (2020). Purification of HCC-specific extracellular vesicles on nanosubstrates for early HCC detection by digital scoring. Nat Commund., 11, 4489. [PubMed]
    Related Products
    Methyltetrazine-NHS Ester

    An amine-reactive building block.