TCO-PNB Ester is an amine-reactive building block used for modification of amine-containing molecule in organic media. TCO-PNB Ester is supplied as a single axial (major) diastereomer. Specially formulated crystalline provides easy handling and extended shelf life.
Important Product Information:
TCO-PNB Ester is not recommended for labeling of proteins in aqueous buffers due to poor level of activation of labeled proteins (Rahim, M.K., et al., Bioconjugate Chem. 2015, 26, 352-360). TCO-PEG4-NHS Ester and TCO-PEG12-NHS Ester are well suited for protein and antibody labeling in aqueous buffers.