TCO-PEG4-TFP Ester

Catalog#
Unit Size
Price (USD)
Availability
Qty
1398-2
4 x 2 mg
$149.00
In stock
1398-10
10 mg
$95.00
In stock
1398-25
25 mg
$195.00
In stock
1398-100
100 mg
$495.00
In stock

TCO-PEG4-TFP Ester is an amine-reactive labeling reagent used to modify proteins, antibodies, and other amine-containing biopolymers. A 2,3,5,6-tetrafluorophenol (TFP) is a reactive ester that displays much better stability toward hydrolysis in aqueous media resulting in more efficiency and better reproducible labeling of biopolymers. TFP ester of carboxylic acids react with primary amines at the same rate as NHS ester forming covalent amide bond that is identical to one formed by the reaction between primary amines and NHS esters or sulfo-NHS esters.

Molecular weight
565.56
Chemical composition
C26H35F4NO8
CAS
N/A
Solubility
DMSO, DMF, THF, Acetonitrile, Dichloromethane
Purity
>95% (HPLC)
Appearance
Colorless to slightly yellow oil
Storage conditions
-20°C. Desiccate
Shipping conditions
Ambient temperature

TCO-PEG4-TFP Ester is an amine-reactive, labeling reagent used to modify proteins, antibodies, and other amine-containing biopolymers. The hydrophilic polyethylene glycol (PEG) spacer arm imparts water solubility and provides a long and flexible connection that minimizes steric hindrance involved with ligation to complementary tetrazine-containing molecules.

The N-hydroxysuccinimide (NHS, also known as HOSu) esters of carboxylic acids are the most widely used reactive esters for modifying amine-containing peptides and proteins. NHS esters are notorious for having a short, pH-dependent half-life in aqueous media. A 2,3,5,6-tetrafluorophenol (TFP) is a different type of reactive ester that displays much better stability toward hydrolysis in aqueous media resulting in more efficiency and better reproducible labeling of biopolymers. TFP ester of carboxylic acids react with primary amines at the same rate as NHS ester forming covalent amide bond that is identical to one formed by the reaction between primary amines and NHS esters or sulfo-NHS esters.

Related Products
Click-&-Go™ Protein Reaction Buffer Kit

A click chemistry reaction buffer kit optimized for cell lysates labeling.

labeling kit$145.00