TCO-NHS Ester (equatorial)

Catalog#
Unit Size
Price (USD)
Availability
Qty
1016-25
25 mg
$145.00
In stock
1016-100
100 mg
$435.00
In stock
1016-1000
1000 mg
$1,950.00
In stock

    TCO-NHS Ester is an amine-reactive building block used for modification of amine-containing molecule in organic media. TCO-NHS ester is supplied as a single equatorial (major, rel-(1S-2S-5E-pR), ref 1 and 4) diastereomer. Specially formulated crystalline provides easy handling and extended shelf life.

    Important Product Information:
    TCO-NHS Ester is not recommended for labeling of proteins in aqueous buffers due to poor level of activation of labeled proteins (Rahim, M.K., et al., Bioconjugate Chem. 2015, 26, 352-360). TCO-PEG4-NHS Ester is well suited for protein and antibody labeling in aqueous buffers.

    Molecular weight
    267.28
    Chemical composition
    C13H17NO5
    CAS
    1191901-33-3
    Solubility
    DMSO, DMF, DCM, THF, Chloroform
    Purity
    >95% (HPLC)
    Appearance
    White to slightly grey crystalline
    Storage conditions
    -20°C. Desiccate
    Shipping conditions
    Ambient temperature

    1. Royzen, M., et al. (2008). A Photochemical Synthesis of Functionalized trans-Cyclooctenes Driven by Metal Complexation. J. AM. CHEM. SOC., 130: 3760-1. [PubMed]
    2. Blackman, M.L., et al. (2008). Tetrazine ligation: fast bioconjugation based on inverse-electron-demand Diels-Alder reactivity. J. AM. CHEM. SOC., 130: 13518-9. [PubMed]
    3. Rahim, M.K., et al. (2015). Enhancing Reactivity for Bioorthogonal Pretargeting by Unmasking Antibody-Conjugated trans-Cyclooctenes. Bioconjugate Chem., 26: 352-60. [PubMed]
    4. Rossin, R., et al. (2013). Highly Reactive trans-Cyclooctene Tags with Improved Stability for Diels−Alder Chemistry in Living Systems. Bioconjugate Chem., 24: 1210-7. [PubMed]
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