TBTA was introduced shortly after the copper-catalyzed azide-alkyne cycloaddition reaction was discovered to mitigate thermodynamic instability of Cu(I) in aerobic media. TBTA is a water-insoluble ligand and must be first dissolved in DMSO or DMF.
DMSO, DMF, DCM, THF, Chloroform
Off-white to grey solid
- Pratt Matthew R., et al. (2020). Acetylated Chemical Reporters of Glycosylation Can Display Metabolism-Dependent Background Labeling of Proteins but Are Generally Reliable Tools for the Identification of Glycoproteins. Frontiers in Chemistry, 8, 318. [Frontiers in Chemistry]