Sulfo TCO-Maleimide a water-soluble reagent that enables simple and efficient incorporation of TCO moiety onto cysteine-containing peptides or other thiol-containing molecules. The maleimide group specifically and efficiently reacts with reduced thiols (sulfhydryl groups, –SH) at pH 6.5 to 7.5 to form stable thioether bonds. The hydrophilic sulfonated spacer arm greatly improves water solubility of TCO derivatized molecules, in many cases making it completely soluble in aqueous media. A short spacer arm adds minimal mass to modified molecules
A mid-length, sulfhydryl-reactive labeling reagent with enhanced water-solubility provided by a PEG4 spacer.
An amine-reactive labeling reagents with enhanced reactivity and water solubility.
An amine-reactive labeling reagents with enhanced solubility in aqueous buffers.