O-propargyl-puromycine (OPP)

Catalog#
Unit Size
Price (USD)
Availability
Qty
1407-5
5 mg
$295.00
In stock
1407-25
25 mg
$1,095.00
In stock
1407-100
100 mg
$2,795.00
In stock

O-propargyl-puromycin (OPP) is an alkyne analog of puromycin that is efficiently incorporated into newly translated proteins, which are rapidly turned over by the proteasome and can be visualized or captured by copper(I)-catalyzed azide-alkyne cycloaddition. Unlike methionine analogs, OPP does not require methionine-free conditions and, uniquely, can be used to label and assay nascent proteins in whole organisms.

Molecular weight
495.54
Chemical composition
C24H29N7O5
CAS
1416561-90-4
Solubility
DMSO, DMF
Purity
>95% (HPLC)
Appearance
Off-white to slightly grey crystalline
Storage conditions
-20°C.
Shipping conditions
Ambient temperature

1. Lui, J., et al. (2012). Imaging protein synthesis in cells and tissues with an alkyne analog of puromycin. PNAS, 109, 413-8. [PubMed]

2. Forester, C.M., et al. (2018). Revealing nascent proteomics in signaling pathways and cell differentiation.PNAS, 115, 2353-8. [PubMed]

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