L-Homopropargylglycine (HPG)

Catalog#
Unit Size
Price (USD)
Availability
Qty
1067-25
25 mg
$125.00
In stock
1067-100
100 mg
$255.00
In stock
1067-1000
1000 mg
$1,255.00
In stock

    L-Homopropargylglycine (HPG) is an amino acid analog of methionine that contains a very small modification, specifically an alkyne moiety that can be fed to cultured cells and incorporated into proteins during active protein synthesis. Detection utilizes the chemoselective ligation or “click ” reaction between an azide and an alkyne or cyclooctyne. The alkyne-modified protein is detected with either fluorescent azide or biotin azide. Detection sensitivity with these reagents in 1-D gels and Western blots is in the low femtomole range and compatible with downstream LC-MS⁄MS and MALDI MS analysis.

    Molecular weight
    163.60 (HCl salt)
    Chemical composition
    C6H10ClNO2
    CAS
    942518-19-6
    Solubility
    Water, DMSO, DMF
    Purity
    >95% (H NMR)
    Appearance
    White crystalline
    Storage conditions
    -20°C
    Shipping conditions
    Ambient temperature

    1. Couradeau, E., et al. (2019). Probing the active fraction of soil microbiomes using BONCAT-FACS Nat Commun, 10, 2770-80. [PubMed]
    Related Products
    Biotin Azide

    An azide-activated biotinylation reagent.