L-Homopropargylglycine (HPG)

Catalog#
Unit Size
Price (USD)
Availability
Qty
1067-25
25 mg
$115.00
In stock
1067-100
100 mg
$235.00
In stock
1067-1000
1000 mg
$1,195.00
In stock

L-Homopropargylglycine (HPG) is an amino acid analog of methionine that contains a very small modification, specifically an alkyne moiety that can be fed to cultured cells and incorporated into proteins during active protein synthesis. Detection utilizes the chemoselective ligation or “click ” reaction between an azide and an alkyne or cyclooctyne. The alkyne-modified protein is detected with either fluorescent azide or biotin azide. Detection sensitivity with these reagents in 1-D gels and Western blots is in the low femtomole range and compatible with downstream LC-MS⁄MS and MALDI MS analysis.

Molecular weight
163.60 (HCl salt)
Chemical composition
C6H10ClNO2
CAS
942518-19-6
Solubility
Water, DMSO, DMF
Purity
>95% (H NMR)
Appearance
White crystalline
Storage conditions
-20°C
Shipping conditions
Ambient temperature

1. Couradeau, E., et al. (2019). Probing the active fraction of soil microbiomes using BONCAT-FACS Nat Commun, 10, 2770-80. [PubMed]

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