F-ara-EdU is a probe for DNA synthesis that is less toxic compared to 5-ethynyl-2′-deoxyuridine (EdU) and BrdU. Ideally suited for metabolic DNA labeling experiments where long-term cell survival and/or deep-tissue imaging are desired. The alkyne handler can be used for subsequent ligation to azide-containing molecules through a highly efficient click chemistry reaction.
- Neef, A.B., et al. (2011). Dynamic metabolic labeling of DNA in vivo with arabinosyl nucleosides. PNAS,, 108, 20404-9. [PubMed]