Dde Biotin Picolyl Azide

Catalog#
Unit Size
Price (USD)
Availability
Qty
1186-5
5 mg
$129.00
In stock
1186-10
10 mg
$225.00
In stock
1186-100
100 mg
$1,295.00
In stock

    Dde Biotin Picolyl Azide is an azide-activated cleavable biotin probe that allows for efficient recovery of avidin-bound protein complexes in affinity-based assays. This reagent contains a biotin moiety linked to azide group through a spacer arm containing a hydrazine-cleavable Dde moiety. Under mild conditions (2% aqueous hydrazine), the Dde liner is cleaved, releasing the biotin tag and any avidin conjugate bound to it.

    Molecular weight
    815.98
    Molecular weight left behind
    220.24
    Chemical composition
    C38H57N9O9S
    CAS
    2055048-42-3
    Solubility
    DMSO, DMF, THF, DCM, Chloroform
    Appearance
    Oil to amorphous solid
    Storage conditions
    -20°C.
    Shipping conditions
    Ambient temperature

    1. Matthew E. G., et al. (2017). Comprehensive Mapping of O-GlcNAc Modification Sites Using a Chemically Cleavable Tag. Mol. Biosyst, 12: 1756–59. [PubMed]
    2. Gertsik N., et al. (2017). Mapping the Binding Site of BMS-708163 on y-Secretase with Cleavable Photoprobes. Cell Chemical Biology, 32: 3-8. [PubMed]
    3. Jiang, H., et al. (2014). Monitoring Dynamic Glycosylation in Vivo Using Supersensitive Click Chemistry. Bioconjugate Chem., 25: 698-706. [PubMed]
    4. Yang Y., et al. (2013). Cleavable Trifunctional Biotin Reagents for Protein Labeling, Capture, and Release. Chem. Commun., 48: 5366-86. [PubMed]
    5. Uttamapinant, C., et al. (2012). Fast, Cell-Compatible Click Chemistry with Copper-Chelating Azides for Biomolecular Labeling. Angew. Chem. Int. Ed,. 51: 5852–56. [PubMed]
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