DBCO-Sulfo-NHS Ester

Catalog#
Unit Size
Price (USD)
Availability
Qty
A124-10
10 mg
$115.00
In stock
A124-25
25 mg
$245.00
In stock
A124-100
100 mg
$545.00
In stock
A124-500
500 mg
$1,820.00
In stock

    DBCO-Sulfo-NHS Ester is water-soluble reagent that enables simple and efficient labeling of antibodies, proteins and any other primary amine-containing macromolecules with DBCO moiety in 100% aqueous buffers. It reacts with primary amines (e.g., side chain of lysine residues or aminosilane-coated surfaces) at neutral or slightly basic pH to form covalent bonds.

    Molecular weight
    532.50
    Chemical composition
    C25H21N2NaO8S
    CAS
    1400191-52-7
    Solubility
    Water, DMSO, DMF
    Purity
    >95% (HPLC)
    Appearance
    White to slightly grey crystalline
    Storage conditions
    -20°C. Desiccate
    Shipping conditions
    Ambient temperature

    DBCO-Sulfo-NHS Ester Ester is water-soluble reagent that enables simple and efficient labeling of antibodies, proteins and any other primary amine-containing macromolecules with DBCO moiety in 100% aqueous buffers. It reacts with primary amines (e.g., side chain of lysine residues or aminosilane-coated surfaces) at neutral or slightly basic pH to form covalent bonds. DBCO-Sulfo-NHS Ester is a reagent of choice for applications that cannot tolerate organic co-solvents or are complicated by their inclusion. Specific labeling of cell surface proteins is another common application for these uniquely water-soluble and membrane impermeable reagents.

    DBCO reagents, also known as ADIBO or DIBAC, are the most commonly used substrates for strain-promoted click chemistry reaction. DBCO compounds react with azide functionalized compounds or biomolecules without the need for a Cu(I) catalyst to result in a stable triazole linkage.

    Enter only one — either volume or amount of protein to be labeled
    Enter only one — either maximum concentration of DMSO or volume DMSO added to label
    1. Wiener, J., et al. (2020). Preparation of single- and double-oligonucleotide antibody conjugates and their application for protein analytics. Sci Rep., 10 (1), 1457. [PubMed]
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