DBCO-PEG4-NHS Ester

Catalog#
Unit Size
Price (USD)
Availability
Qty
A134-2
4 x 2 mg
$129.00
In stock
A134-10
10 mg
$95.00
In stock
A134-25
25 mg
$195.00
In stock
A134-100
100 mg
$495.00
In stock
A134-500
500 mg
$1,695.00
In stock

DBCO-PEG4-NHS Ester reacts specifically and efficiently with a primary amine (e.g., side chain of lysine residues or aminosilane-coated surfaces) at pH 7-9 to form a covalent bond. The hydrophilic polyethylene glycol (PEG) spacer arm imparts water solubility and provides a long and flexible connection that minimizes steric hindrance involved with ligation to complementary azide-containing molecules.

Molecular weight
649.68
Chemical composition
C34H39N3O10
CAS
1427004-19-0
Solubility
DMF, DMSO, DCM, THF, Chloroform
Purity
>95% (HPLC)
Appearance
Yellow to slightly orange oil
Storage conditions
-20°C. Desiccate
Shipping conditions
Ambient temperature

1. Nedrow-Byerst, J.R., et al. (2013). PSMA-targeted SPECT agents: mode of binding effect on in vitro performance. Prostate., 73(4), 355-62. [PubMed]

2. Ahn, S.H., et al. (2020). Site-Specific 89Zr- and 111In-Radiolabeling and In Vivo Evaluation of Glycan-free Antibodies by Azide–Alkyne Cycloaddition with a Non-natural Amino Acid. Bioconjugate Chem., 31(4), 1177-87. [PubMed]

3. Huynh, V., et al. (2018). Competitive Affinity Release for Long-Term Delivery of Antibodies from Hydrogels. Bioconjugate Chem., 57(13), 3406-10. [PubMed]

4. Pack, J., et al. (2020). Site-Specific Antibody Conjugation Strategy to Functionalize Virus-Based Nanoparticles. Bioconjugate Chem., 31(5), 1408-16. [PubMed]

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