DBCO-PEG4-NHS Ester

Catalog#
Unit Size
Price (USD)
Availability
Qty
A134-10
10 mg
$115.00
In stock
A134-2
4 x 2 mg
$129.00
In stock
A134-25
25 mg
$215.00
In stock
A134-100
100 mg
$535.00
In stock
A134-500
500 mg
$1,795.00
In stock

    DBCO-PEG4-NHS Ester reacts specifically and efficiently with a primary amine (e.g., side chain of lysine residues or aminosilane-coated surfaces) at pH 7-9 to form a covalent bond. The hydrophilic polyethylene glycol (PEG) spacer arm imparts water solubility and provides a long and flexible connection that minimizes steric hindrance involved with ligation to complementary azide-containing molecules.

    Molecular weight
    649.68
    Chemical composition
    C34H39N3O10
    CAS
    1427004-19-0
    Solubility
    DMF, DMSO, DCM, THF, Chloroform
    Purity
    >95% (HPLC)
    Appearance
    Yellow to slightly orange oil
    Storage conditions
    -20°C. Desiccate
    Shipping conditions
    Ambient temperature

    1. Wang X., et al. (2021). Equipping Natural Killer Cells with Cetuximab through Metabolic Glycoengineering and Bioorthogonal Reaction for Targeted Treatment of KRAS Mutant Colorectal Cancer. ACS Chem. Biol., 16 (4), 724-730. [PubMed]
    2. Wiener, J., et al. (2020). Preparation of single- and double-oligonucleotide antibody conjugates and their application for protein analytics. Sci Rep., 10 (1), 1457. [PubMed]
    3. Ahn, S.H., et al. (2020). Site-Specific 89Zr- and 111In-Radiolabeling and In Vivo Evaluation of Glycan-free Antibodies by Azide–Alkyne Cycloaddition with a Non-natural Amino Acid. Bioconjugate Chem., 31(4), 1177-87. [PubMed]
    4. Pack, J., et al. (2020). Site-Specific Antibody Conjugation Strategy to Functionalize Virus-Based Nanoparticles. Bioconjugate Chem., 31(5), 1408-16. [PubMed]
    5. Miller, A. L., et al. (2019). Rapid conjugation of nanoparticles, proteins and siRNAs to microbubbles by strain-promoted click chemistry for ultrasound imaging and drug delivery†. Polym. Chem., 10, 705-717. [Publishing]
    6. Huynh, V., et al. (2018). Competitive Affinity Release for Long-Term Delivery of Antibodies from Hydrogels. Bioconjugate Chem., 57(13), 3406-10. [PubMed]
    7. Nedrow-Byerst, J.R., et al. (2013). PSMA-targeted SPECT agents: mode of binding effect on in vitro performance. Prostate., 73(4), 355-62. [PubMed]
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