DBCO-PEG4-Maleimide

Catalog#
Unit Size
Price (USD)
Availability
Qty
A108P-10
10 mg
$115.00
In stock
A108P-25
25 mg
$215.00
In stock
A108P-100
100 mg
$539.00
In stock
A108P-500
500 mg
$1,795.00
In stock

    DBCO-PEG4-Maleimide enables simple and efficient incorporation of DBCO moiety onto antibodies, cysteine-containing peptides and other thiol-containing molecules. The maleimide group specifically and efficiently reacts with reduced thiols (sulfhydryl groups, –SH) at pH 6.5 to 7.5 to form stable thioether bonds. The hydrophilic polyethylene glycol (PEG) spacer arm improves solubility in aqueous buffers.

    Molecular weight
    674.74
    Chemical composition
    C36H42N4O9
    CAS
    1480516-75-3
    Solubility
    DMSO, DMF, THF, Acetonitrile, Dichloromethane
    Purity
    >95% (HPLC)
    Appearance
    Yellow to slightly orange oil
    Storage conditions
    -20°C. Desiccate
    Shipping conditions
    Ambient temperature

    1. Esser-Kahn, A. P., et al. (2020). Pathogen-like Nanoassemblies of Covalently Linked TLR Agonists Enhance CD8 and NK Cell-Mediated Antitumor Immunity. ACS Cent. Sci., 10, 1021. [ACS Publications]
    2. Kiseleva, R., et al. (2020). MBivalent engagement of endothelial surface antigens is critical to prolonged surface targeting and protein delivery in vivo. FASEB Jornal, 34, 9, 11577-93. [FASEB]
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