DBCO-NHS Ester

Catalog#
Unit Size
Price (USD)
Availability
Qty
A133-25
25 mg
$115.00
In stock
A133-100
100 mg
$245.00
In stock
A133-1000
1000 mg
$1,050.00
In stock
A133-5G
5 g
$3,750.00
In stock

DBCO-NHS Ester, also known as ADIBO-NHS Ester or DIBAC-NHS Ester, is an amine-reactive building block used for modification of amine-containing molecule in organic media. It reacts with primary amines (e.g., side chain of lysine residues or aminosilane-coated surfaces) at neutral or slightly basic pH to form covalent bonds. Short spacer arm adds minimal mass to modified molecules (228.3 daltons).

This product is not recommended for labeling of proteins or any other biopolymers in aqueous buffers due to poor aqueous solubility.

Molecular weight
402.40
Chemical composition
C23H18N2O5
CAS
1353016-71-3
Solubility
DMSO, DMF, DCM, THF, Chloroform
Purity
>95% (HPLC)
Appearance
White to slightly grey crystalline
Storage conditions
-20°C. Desiccate
Shipping conditions
Ambient temperature

1. Campbell-Verduyn, L.S., et al. (2011). Strain-promoted copper-free “click” chemistry for 18F radiolabeling of bombesin. Angew Chem Int Ed., 50(47), 11117-20. [PubMed]

2. Meyer, A.M., et al. (2020). Programmable Assembly of Iron Oxide Nanoparticles Using DNA Origami. Nano Lett., 20(4), 2799-805. [PubMed]

3. Saikatr, M., et al. (2015). A Three-Arm Scaffold Carrying Affinity Molecules for Multiplex Recognition Imaging by Atomic Force Microscopy: The Synthesis, Attachment to Silicon Tips, and Detection of Proteins J. Am. Chem. Soc., 137(23), 7415-25. [PubMed]

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