DBCO-C6-NHS Ester is an amine-reactive building block used for modification of amine-containing molecule in organic media. The extended 6-carbon atom spacer arm drastically improves solubility of this reagent in commonly used organic solvents such as dichloromethane, chloroform, THF, and ethyl acetate. In addition extended spacer arm significantly improves derivatization efficiency and stability of conjugates.
This product is not recommended for labeling of proteins or any other biopolymers in aqueous buffers due to poor aqueous solubility.
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- Saikatr, M., et al. (2015). A Three-Arm Scaffold Carrying Affinity Molecules for Multiplex Recognition Imaging by Atomic Force Microscopy: The Synthesis, Attachment to Silicon Tips, and Detection of Proteins J. Am. Chem. Soc., 137(23), 7415-25. [PubMed]
A water-soluble labeling reagent with improved labeling efficiency.
A water-soluble activated ester for modification of primary amine-containing molecules with sulfo DBCO moiety.