DBCO Amine
Catalog#
Unit Size
Price (USD)
Availability
Qty
A103-25
25 mg
$115.00
In stock
A103-100
100 mg
$265.00
In stock
A103-1000
1000 mg
$1,350.00
In stock
A103-5G
5 g
$4,250.00
In stock
DBCO Amine is a simple DBCO-containing building block used to derivatize carboxyl groups in the presence of activators (e.g. EDC, or DCC) or activated esters (e.g. NHS esters) with DBCO moiety through a stable amide bond.
DBCO reagents, also know as ADIBO or DIBAC are the most commonly used substrates for copper-free click reaction. DBCO compounds react with azide functionalized compounds or biomolecules without the need for a Cu(I) catalyst to result in a stable triazole linkage.
Molecular weight
276.33
Chemical composition
C18H16N2O
CAS
1255942-06-3
Solubility
DMSO, DMF, DCM, THF, Chloroform
Purity
>95% (HPLC)
Appearance
Slightly yellow to slightly crystalline
Storage conditions
-20°C. Desiccate
Shipping conditions
Ambient temperature
- Davis, G. J., et al. (2021). Copper-Free Click Enabled Triazabutadiene for Bioorthogonal Protein Functionalization. Bioconjugate Chem., 32 (2), 254-258. [PubMed]
- Kakwere, K., et al. (2018). Unimicellar hyperstars as multi-antigen cancer nanovaccines displaying clustered epitopes of immunostimulating peptides. Biomater. Sci., 6, 5850-8. [PubMed]
- Zeng D., et al. (2012). 64Cu Core-labeled Nanoparticles with High Specific Activity via Metal-Free Click Chemistry. ACS Med Chem Lett., 6(6), 5209–19. [PubMed]
- Bouvet, V., et al. (2011). Copper-free click chemistry with the short-lived positron emitter fluorine-18. Org Biomol Chem., 9(21), 7393-9. [PubMed]
- Carpenter, R.D., et al. (2011). Copper-Free Click for PET: Rapid 1,3-Dipolar Cycloadditions with a Fluorine-18 Cyclooctyne. ACS Med Chem Lett., 2(12), 885-9. [PubMed]
- Arumugam S., et al. (2011). [18F]azadibenzocyclooctyne ([18F]ADIBO): a biocompatible radioactive labeling synthon for peptides using catalyst free [3+2] cycloaddition. Bioorg Med Chem Lett., 21(23), 6987-91. [PubMed]
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