Cy7 Methyltetrazine

Catalog#
Unit Size
Price (USD)
Availability
Qty
1027-1
1 mg
$149.00
In stock
1027-5
5 mg
$495.00
In stock
1027-25
25 mg
$1,480.00
In stock

    Methyltetrazine-activated Cy7 probe that reacts with TCO-containing compounds via an Inverse-Electron-Demand Diels-Alder reaction to form a stable covalent bond and does not require Cu-catalyst or elevated temperatures. The inverse-electron demand Diels-Alder cycloaddition reaction of TCO with tetrazines is a bioorthogonal reaction that possesses exceptional kinetics (k > 800 M-1 s -1) and selectivity. Such excellent reaction rate constants are unparalleled by any other bioorthogonal reaction pair described to date.

    Abs/Em Maxima
    753/775 nm
    Extinction Coefficient
    255,000
    Spectrally Similar Dyes
    Alexa Fluor® 750, IRDye® 750, CF® 750 Dye, DyLight® 750
    Molecular weight
    1184.42
    CAS
    N/A
    Solubility
    Water, DMSO, DMF, MeOH
    Purity
    >95% (HPLC)
    Appearance
    Dark green solid
    Storage conditions
    -20°C. Desiccate
    Shipping conditions
    Ambient temperature

    Methyltetrazine-activated Cy7 dye that reacts with TCO-containing compounds via a Inverse-Electron-Demand Diels-Alder reaction to form a stable covalent bond and does not require Cu-catalyst or elevated temperatures. The inverse-electron demand Diels-Alder cycloaddition reaction of TCO with tetrazines is a bioorthogonal reaction that possesses exceptional kinetics (k > 800 M-1 s-1) and selectivity. Such excellent reaction rate constants are unparalleled by any other bioorthogonal reaction pair described to date.

    Cy7 Methyltetrazine is a bright and photostable near-IR probe that spectrally similar to Alexa Fluor® 750, DyLight® 750, and IRDye® 750 dye. The Cy7 Methyltetrazine is water-soluble, hydrophilic dye often a reagent of choice for assay where minimal non-specific binding and exceptional brightness is required. The fluorescence of Cy7 Methyltetrazine is pH insensitive from pH 4 to pH 10 and produces minimal autofluorescence of biological specimens in this region of the spectrum. Fluorescence of this long-wavelength Cyanine dye is not visible to the human eye but is readily detected by most imaging systems.

    Cy®Dye is a trademark of GE Healthcare. Alexa Fluor® and DyLight® are registered trademark of Thermo Fisher Scientific. IRDye® is a registered trademark of Li-Cor, Inc

    Cy7

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