Cy3 Tetrazine

Catalog#
Unit Size
Price (USD)
Availability
Qty
1204-1
1 mg
$179.00
In stock
1204-5
5 mg
$579.00
In stock
1204-25
25 mg
$1,890.00
In stock

    Tetrazines demonstrate exceptionally fast cycloaddition kinetics (up to 30 000 M-1 s-1) with trans-cyclooctenes (TCO) as the dienophile, the fastest kinetics ever reported for any bioorthogonal reaction. In addition, inverse-Electron-Demand Diels-Alder reaction of tetrazines trans-cyclooctenea forms a stable covalent bond and does not require Cu-catalyst or elevated temperatures. In applications such as in vivo cancer imaging or pre‐targeted cell labeling studies where rapid reaction kinetics is a must, a faster hydrogen substituted Cy®3 Tetrazine probe would be a probe of choice.

    Abs/Em Maxima
    553/569 nm
    Extinction Coefficient
    150,000
    Flow Cytometry Laser Line
    532 or 555 nm
    Microscopy Laser Line
    532 or 555 nm
    Spectrally Similar Dyes
    Alexa Fluor® 555, CF® 555 Dye, DyLight®555
    Molecular weight
    894.05
    CAS
    N/A
    Solubility
    Water, DMSO, DMF
    Purity
    >95% (HPLC)
    Appearance
    Red solid
    Storage conditions
    -20°C. Desiccate
    Shipping conditions
    Ambient temperature

    Tetrazines demonstrate exceptionally fast cycloaddition kinetics (up to 30 000 M-1 s-1) with trans-cyclooctenes (TCO) as the dienophile, the fastest kinetics ever reported for any bioorthogonal reaction. In addition, inverse-Electron-Demand Diels-Alder reaction of tetrazines trans-cyclooctenea forms a stable covalent bond and does not require Cu-catalyst or elevated temperatures. In applications such as in vivo cancer imaging or pre‐targeted cell labeling studies where rapid reaction kinetics are desired, a faster hydrogen substituted Cy®3 Tetrazine probe would be a probe of choice.

    Cy®3 is a bright, water-soluble, and pH insensitive orange-fluorescent dye that can be excited using the 532 nm or 555 nm laser line and visualized with TRITC (tetramethylrhodamine) filter sets. Cy3 conjugates give less background than TAMRA and most other commonly used fluorescent dyes.

    Cy®Dye is a trademark of GE Healthcare.

    Cy3

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