BTTP is a newest generation, accelerating ligand for CuAAC that provides much greater rate enhancement compared to previous generation ligands (e.g. THPTA or TBTA). More importantly, it minimizes perturbations to the physiological state of the cells or organisms probed and allows for effective bioconjugation with suppressed cell cytotoxicity by further lowering copper loading in the catalyst formulation.
1. Maiyun, Y., et al. (2014). Biocompatible click chemistry enabled compartment-specific pH measurement inside E. coli. Nature Communications. 5: 4981. [PubMed]
2. Wang, W., et al. (2011). Sulfated ligands for the copper(I)-catalyzed azide-alkyne cycloaddition. Chem Asian J., 6(10), 2796-802. [PubMed]
An azide-activated biotinylation reagent.
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