Biotin Picolyl Azide

Catalog#
Unit Size
Price (USD)
Availability
Qty
1167-5
5 mg
$149.00
In stock
1167-25
25 mg
$345.00
In stock
1167-100
100 mg
$1,095.00
In stock

    Biotin Picolyl Azide is an advanced biotin probe that incorporates a copper-chelating motif to raise the effective concentration of Cu(I) at the reaction site to boosted the efficiency of the CuAAC reaction resulting in a faster and more biocompatible CuAAC labeling. Up to 40-fold increase of signal intensity, compared to conventional azides was reported (see Selected References).

    Learn more about picolyl azide reagents.

    Molecular weight
    622.74
    Chemical composition
    C27H42N8O7S
    CAS
    N/A
    Solubility
    DMSO, DMF
    Purity
    >95% (HPLC)
    Appearance
    Off-white to slightly orange amorphous solid
    Storage conditions
    -20°C. Desiccate
    Shipping conditions
    Ambient temperature

    1. Wood, T. M., et al. (2021). Optimization of Metabolic Oligosaccharide Engineering with Ac4GalNAlk and Ac4GlcNAlk by an Engineered Pyrophosphorylase. ACS Chem. Biol., [PubMed]
    2. Banerjee, A.K.,et al. (2020). SARS-CoV-2 disrupts splicing, translation, and protein trafficking to suppress host defenses. Cells., [Cell]
    3. Gaebler, A.,et al. (2016). A highly sensitive protocol for microscopy of alkyne lipids and fluorescently tagged or immunostained proteins. J. Lipid. Res., 57, 1934-47. [PubMed]
    4. Jiang, H., et al. (2014). Monitoring Dynamic Glycosylation in Vivo Using Supersensitive Click Chemistry. Bioconjugate Chem.,, 25, 698-706. [PubMed]
    5. Uttamapinant, C., et al. (2012). Fast, Cell-Compatible Click Chemistry with Copper-Chelating Azides for Biomolecular Labeling. Angew. Chem. Int. Ed,., 51, 5852-56. [PubMed]
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