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The traditional sulfhydryl labeling chemistry cleaves disulfide bridges and leaves them in “open form”, which may compromise the stability and function of an antibody or other proteins. Biotin-PEG3-Bis-sulfone re-bridges the disulfide bond, and enhances the structural stability of the protein. In addition, conjugates prepared with ThioLinkerTM reagents benefits from reduced heterogeneity and better stability.
Learn more about bis-alkylating reagents.