Alkynyl Palmitic Acid

Catalog # Pkg Size Price(USD) Quantity
1165-5 5 mg $79.00
1165-25 25 mg $195.00
1165-100 100 mg $495.00

Alkynyl palmitic acid (15-hexadecynoic acid or Palmitic acid (15-yne)) is a modified palmitic acid with an ω-terminal alkyne. Alkynyl palmitic acid often used to identify and characterize the post-translational S-palmitoylation of proteins using the powerful click chemistry (see References).

1. Tallman, K.A., et al. (2013). Cobalt carbonyl complexes as probes for alkyne-tagged lipids. Chem. J Lipid Res, 54, 859-68. [PubMed]

2. Milne, S.B., et al. (2010). Capture and release of alkyne-derivatized glycerophospholipids using cobalt chemistry. Nat Chem Biol , 6, 205-7. [PubMed]

3. Jiang, H.,et al. (2013). SIRT6 regulates TNF-alpha secretion through hydrolysis of long-chain fatty acyl lysine. Nature 496, 110-3. [PubMed]

4. Thiele, C., et al. (2012). Tracing fatty acid metabolism by click chemistry. ACS Chem Biol , 7, 2004-11. [PubMed]

5. Gao, X. N., et al. (2011). Membrane targeting of palmitoylated Wnt and Hedgehog revealed by chemical probes. FEBS Lett , 585, 2501-6. [PubMed]

6. Yap, M.C., et al. (2010). Rapid and selective detection of fatty acylated proteins using omega-alkynyl-fatty acids and click chemistry. J Lipid Res , 51, 1566-80. [PubMed]

7. Martin, B.R., et al. (2009). ). Large-scale profiling of protein palmitoylation in mammalian cells. Nat Methods , 6, 135-8. [PubMed]