Alkynyl Myristic Acid
Alkynyl myristic acid is can be used to identify and characterize the post-translational myristylated proteins using a simple and robust two-step labeling and detection technique. Due to the very small size of the alkyne group and its complete absence in any natural molecules the presence of the alkyne group does not affect the biodistribution of alkynyl myristic acid in comparison to the natural palmitic acid making it a suitable substrate for enzymes.
- Gray, R. A. V., et al. (2021). Optimized Incorporation of Alkynyl Fatty Acid Analogs for the Detection of Fatty Acylated Proteins using Click Chemistry. JoVE Journal, 10 (3791), 62107. [JoVE Journal]