Alkyne Sphinganine

Catalog#
Unit Size
Price (USD)
Availability
Qty
1452-1
1 mg
$159.00
In stock
1452-5
5 mg
$495.00
In stock
1452-25
25 mg
$1,490.00
In stock

    Alkyne Sphinganine a metabolic labeling reagent that contains a terminal alkyne moiety that allows for the subsequent tagging of protein−lipid complexes by click chemistry. The terminal alkyne group can be used in a highly specific linking reaction with azide-containing reagents, known as ‘click chemistry’, in the presence of a copper (Cu)-containing catalyst allowing for the visualization and proteomic profiling of protein−sphingolipid complexes in living cells.

    Molecular weight
    297.46
    Chemical composition
    C18H35NO2
    CAS
    n/a
    Solubility
    DMSO, DMF
    Purity
    >95% (H NMR)
    Appearance
    White crystalline
    Storage conditions
    -20°C.
    Shipping conditions
    Ambient temperature

    1. Gaebler A., et al. (2016). A highly sensitive protocol for microscopy of alkyne lipids and fluorescently tagged or immunostained proteins. J. Lipid Res., 57, 1934-47. [PubMed]
    2. Gaebler A., et al. (2013). Alkyne lipids as substrates for click chemistry-based in vitro enzymatic assays. J. Lipid Res., 54, 2282-90. [PubMed]
    3. Lee, M.T., et al. (2020). Dietary sphinganine is selectively assimilated by members of themammaliangut microbiome. J Lipid Res . [PubMed]
    Related Products
    AZDye 647 Azide

    Excitation maximum: 648 nm
    Emission maximum: 671 nm

    AZDye 488 Azide

    Excitation maximum: 494 nm
    Emission maximum: 517 nm

    Biotin Azide

    An azide-activated biotinylation reagent.