6-Azidohexanoic Acid

Catalog#
Unit Size
Price (USD)
Availability
Qty
1250-1G
1 g
$179.00
In stock
1250-5G
5 g
$295.00
In stock
1250-25G
25 g
$979.00
In stock

    6-Azidohexanoic acid is a six carbon saturated fatty acid with an ω-terminal azide group. This building block that can be reacted with primary amine groups in the presence activators (e.g. EDC, or DCC) forming a stable amide bond. The terminal azide group allows conjugation with compounds containing alkyne groups through a copper(I)-catalyzed cycloaddition reaction, also known as click chemistry. 6-Azidohexanoic acid is commonly used as a linker that is first acylated to one compound to create a derivative that can then be joined to another compound using click chemistry.

    Molecular weight
    157.17
    Chemical composition
    C6H11N3O2
    CAS
    79598-53-1
    Solubility
    DMSO, DMF, DCM, THF, Chloroform
    Purity
    >95% (H NMR)
    Appearance
    Colorless to slightly yellow oil
    Storage conditions
    -20°C.
    Shipping conditions
    Ambient temperature

    1. Esser-Kahn, A. P., et al. (2020). Pathogen-like Nanoassemblies of Covalently Linked TLR Agonists Enhance CD8 and NK Cell-Mediated Antitumor Immunity. ACS Cent. Sci., 10, 1021. [ACS Publications]
    2. Manna, S., et al. (2018). Immunomodulation of the NLRP3 Inflammasome through Structure-Based Activator Design and Functional Regulation via Lysosomal Rupture. ACS Cent. Sci., 4(8), 982-95. [PubMed]
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